N’-Nitro-N-nitroso-N-methylguanidine (Stabilized with Water)

• CAT Number: R048266
• CAS Number: 70-25-7
• Molecular Formula: C2H5N5O3
• Molecular Weight: 147.094
• Purity: ≥95%
• Synonyms: N-Methyl-N’-nitro-N-nitroso-guanidine; 1-Methyl-1-nitroso-2-nitroguanidine; Methylnitronitrosoguanidine; N-Nitrosoguanidine; N-Nitroso-N’-nitro-N-methylguanidine; 1-Methyl-3-nitro-1-nitrosoguanidine; MNNG; NSC 9369
• Target: Cell Cycle/DNA Damage
• Storage: -20°C
• IUPAC Name: 1-methyl-3-nitro-1-nitrosoguanidine
• InChI: InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)
• InChIKey: VZUNGTLZRAYYDE-UHFFFAOYSA-N
• SMILES: CN(C(=N[N+](=O)[O-])N)N=O

N’-Nitro-N-nitroso-N-methylguanidine(CAT: R048266) holds significance in the realm of toxicology and biological testing. It is utilized as a DNA-damaging agent and serves as a positive control in SHE (Syrian Hamster Embryo) cell transformation assays. These assays are designed to evaluate the potential of substances to induce cellular transformation, which can be indicative of carcinogenicity.

Reference

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2.Tang, Jiang-bo, et al. "Bioenergetic metabolites regulate base excision repair–dependent cell death in response to DNA damage." Molecular Cancer Research 8.1 (2010): 67-79.
3.Zhu, Huifang, et al. "Response of human DNA polymerase ι promoter to N-methyl-N′-nitro-N-nitrosoguanidine." Environmental Toxicology and Pharmacology 29.1 (2010): 79-86.