For research use only. Not for therapeutic Use.
N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling.
| Catalog Number | R066703 |
| CAS Number | 60374-41-6 |
| Synonyms | N-[(9Z)-1-oxo-9-octadecen-1-yl]-L-valine |
| Molecular Formula | C23H43NO3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| InChI | InChI=1S/C23H43NO3/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(25)24-22(20(2)3)23(26)27/h11-12,20,22H,4-10,13-19H2,1-3H3,(H,24,25)(H,26,27)/b12-11-/t22-/m0/s1 |
| InChIKey | LRQPUGFHAACUMH-GJCOWUBNSA-N |
| SMILES | CCCCCCCC/C=CCCCCCCCC(N[C@@H](C(C)C)C(O)=O)=O |
| Reference | 1.Raboune, S.,Stuart, J.M.,Leishman, E., et al. Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation. Front. Cell. Neurosci. 8(195), 1-11 (2014). |
