N-omega-CD3-Octadecanoyl-ceramide trihexoside

For research use only. Not for therapeutic Use.

  • CAT Number: R067977
  • Molecular Formula: C54H98D3NO18
  • Molecular Weight: 1055
  • Purity: ≥95%
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N-omega-CD3-Octadecanoyl-ceramide trihexoside is a deuterated analog of ceramide trihexoside, where the terminal omega position of the octadecanoyl chain is labeled with deuterium (CD3). This isotopically labeled compound is used in biochemical and lipidomics research to study the metabolism, function, and biological roles of ceramides and glycosphingolipids. The deuterium labeling allows for precise tracking in mass spectrometry, facilitating the investigation of lipid metabolism and signaling pathways in various biological systems. N-omega-CD3-Octadecanoyl-ceramide trihexoside is particularly valuable for researchers studying the involvement of glycosphingolipids in diseases such as Gaucher’s disease, Fabry disease, and other lysosomal storage disorders, providing enhanced accuracy and reliable data for therapeutic development and biochemical studies.


Catalog Number R067977
Synonyms

N-C18:0-CD3-CTH; N-C18:0-CD3-Gb3; N-Octadecanoyl-CD3-globotriaosylceramide; N-Stearoyl-CD3-ceramide trihexoside

Molecular Formula C54H98D3NO18
Purity ≥95%
Storage Store at -20°C
Reference

<br>1. S. Ashkenazi and T. G. Cleary, “Rapid method to detect shiga toxin and shiga-like toxin I based on binding to globotriosyl ceramide (Gb3), their naturalreceptor.” J Clin Microbio. June; 27(6): 1145-1150, 1989<br>2. S. Bekri, O. Lidove, R. Jaussaud, B. Knebelmann, F. Barbey. /The role of ceramide trihexoside (globotriaosylceramide) in the diagnosis and follow-up ofthe efficacy of treatment of Fabry disease: a review of the literature/. Cardiovasc Hematol Agents Med Chem 4 (4): 289–97, October 2006<br>3. J. E. Groener, B. J. Poorthuis, S. Kuiper, M. T. Helmond, C. E. Hollak, J. M. Aerts. “HPLC for simultaneous quantification of total ceramide,glucosylceramide, and ceramide trihexoside concentrations in plasma.” Clin Chem., Apr;53(4):742-7, 2007. Epub Mar 1 2007<br>4. K. Mills, A. Johnson, B. Winchester. “Synthesis of novel internal standards for the quantitative determination of plasma ceramide trihexoside in Fabrydisease by tandem mass spectrometry.” FEBS Lett., Mar 27;515(1-3):171-6, 2002<br>5. C. Menge, I. Stamm, M. Wuhrer, R. Geyer, L. H. Wieler, G. Baljer. “Globotriaosylceramide (Gb(3)/CD77) is synthesized and surface expressed bybovine lymphocytes upon activation in vitro.” Vet Immunol Immunopathol., Nov;83(1-2):19-36, 2001</br></br></br></br></br>

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