N-Palmitoyl Glycine

• CAT Number: R025912
• CAS Number: 2441-41-0
• Molecular Formula: C18H35NO3
• Molecular Weight: 313.482
• Purity: ≥95%
• Synonyms: N-Hexadecanoyl-Glycine;PalGly
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: 2-(hexadecanoylamino)acetic acid
• InChI: InChI=1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22)
• InChIKey: KVTFEOAKFFQCCX-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)NCC(=O)O

The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-<wbr></wbr>arachidonoyl ethanolamide (AEA; anandamide). N-<wbr></wbr>palmitoyl glycine (PalGly) contains an 18-<wbr></wbr>carbon saturated fatty acid that is amide-<wbr></wbr>linked to glycine and is structurally similar to the phospholipid-<wbr></wbr>derived N-<wbr></wbr>acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100-<wbr></wbr>fold greater amounts in skin and 3-<wbr></wbr>fold greater in brain compared to AEA. Injection of 0.43 µg PalGly in rat hindpaw inhibits heat-<wbr></wbr>induced firing of nociceptive neurons in rat dorsal horn. PalGly treatment induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-<wbr></wbr>sensitive, DRG-<wbr></wbr>like cell line F-<wbr></wbr>11 (EC50 = 5.5 µM).

Reference

1.Rimmerman, N.,Bradshaw, H.B.,Hughes, H.V., et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Molecular Pharmacology 74(1), 213-224 (2008).