For research use only. Not for therapeutic Use.
2-<wbr></wbr>Palmitoyl glycerol (2-<wbr></wbr>PG) has been isolated along with the potent endocannabinoid 2-<wbr></wbr>arachidonoyl glycerol (2-<wbr></wbr>AG) from various tissues. Although 2-<wbr></wbr>PG displays no intrinsic agonist activity on CB<sub>1</sub> or CB<sub>2</sub> receptors, it does potentiate the ability of 2-<wbr></wbr>AG to inhibit adenylyl cyclase. 2-<wbr></wbr>PG also potentiates the analgesic, hypokinetic, and anxiolytic effects of 2-<wbr></wbr>AG in mice. This “entourage” effect has been attributed to the ability of compounds such as 2-<wbr></wbr>PG to inhibit reuptake and/or compete with the active endocannabinoids for access to inactivating enzymes such as FAAH and monoglyceride lipase. Palmitoyl serinol is a stable analog of 2-<wbr></wbr>PG bearing an amide linkage in place of the labile glyceryl ester. This has the potential to enhance its “entourage” activities as a result of a prolonged <em>in vivo</em> half-<wbr></wbr>life. Palmitoyl serinol is also an analog of C-<wbr></wbr>16 ceramide. Incubation of neuroblastoma cells with palmitoyl serinol causes apoptosis with an IC<sub>50</sub> of approximately 80 µM.
| CAS Number | 126127-31-9 |
| Synonyms | N-[2-hydroxy-1-(hydroxymethyl)ethyl]-hexadecanamide |
| Molecular Formula | C19H39NO3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | N-(1,3-dihydroxypropan-2-yl)hexadecanamide |
| InChI | InChI=1S/C19H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(23)20-18(16-21)17-22/h18,21-22H,2-17H2,1H3,(H,20,23) |
| InChIKey | MZUNFYMZKTWADX-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)NC(CO)CO |
