N-PEG3-N'-(azide-PEG3)-Cy5

• CAT Number: I015672
• CAS Number: 2226235-96-5
• Molecular Formula: C₃₉H₅₄ClN₅O₆
• Molecular Weight: 724.33
• Purity: ≥95%
• Target: PROTAC Linkers

N-PEG3-N’-(azide-PEG3)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562