N-Phenylacetyl-L-homoserine lactone

• CAT Number: R067588
• CAS Number: 55154-48-8
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Purity: ≥95%
• Synonyms: N-[(3S)-2-oxooxolan-3-yl]-2-phenylacetamide
• InChI: InChI=1S/C12H13NO3/c14-11(8-9-4-2-1-3-5-9)13-10-6-7-16-12(10)15/h1-5,10H,6-8H2,(H,13,14)/t10-/m0/s1
• InChIKey: YJTHUPUWKQRCLF-JTQLQIEISA-N
• SMILES: C1COC(=O)C1NC(=O)CC2=CC=CC=C2

N-Phenylacetyl-L-homoserine lactone (PA-HSL) (Cat No.: R067588) is a bacterial quorum sensing (QS) signaling molecule, playing a crucial role in cell-to-cell communication and gene regulation in Gram-negative bacteria. It modulates virulence, biofilm formation, and antibiotic resistance, making it a valuable tool for microbial pathogenesis and antibiotic research. PA-HSL is widely used in quorum sensing studies, bacterial signaling pathway analysis, and drug discovery, aiding in the development of novel antimicrobial strategies to combat bacterial infections and resistance mechanisms.

Reference

[1]. Geske G D, et al. Correction: N-Phenylacetanoyl-l-Homoserine Lactones Can Strongly Antagonize or Superagonize Quorum Sensing in Vibrio fischeri[J]. ACS Chemical Biology, 2007, 2(6): 426-426.