N-Salicyloyltryptamine

• CAT Number: I042926
• CAS Number: 31384-98-2
• Molecular Formula: C17H16N2O2
• Molecular Weight: 280.32
• Purity: ≥95%
• Synonyms: 2-hydroxy-N-[2-(1H-indol-3-yl)ethyl]benzamide
• InChI: InChI=1S/C17H16N2O2/c20-16-8-4-2-6-14(16)17(21)18-10-9-12-11-19-15-7-3-1-5-13(12)15/h1-8,11,19-20H,9-10H2,(H,18,21)
• InChIKey: XBPYTDZHCNJRBY-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)CCNC(=O)C3=CC=CC=C3O

​N-Salicyloyltryptamine（Cat No.:I042926）is a tryptamine derivative that inhibits voltage-dependent Na⁺, Ca²⁺, and K⁺ ion channels, with an IC₅₀ of 34.6 μM for K⁺ currents. It exhibits anticonvulsant properties, reducing seizure incidence in animal models. Additionally, it demonstrates anti-inflammatory and analgesic effects by inhibiting pro-inflammatory cytokines like TNF-α and IL-1β, and modulating NF-κB signaling. N-Salicyloyltryptamine also induces vasorelaxation through activation of the NO/sGC/cGMP pathway and reduction of calcium influx, contributing to its therapeutic potential in cardiovascular conditions. ​