N-tert-butyl-α-Phenylnitrone

• CAT Number: R065044
• CAS Number: 3376-24-7
• Molecular Formula: C11H15NO
• Molecular Weight: 177.3
• Purity: ≥95%
• Synonyms: PBN
• Storage: -20°C
• InChI: InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
• InChIKey: IYSYLWYGCWTJSG-XFXZXTDPSA-N
• SMILES: [O-]/[N+](C(C)(C)C)=CC1=CC=CC=C1

N-tert-butyl-α-Phenylnitrone (PBN) is a cell permeable spin trap commonly used in free radical research. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. At millimolar concentrations, PBN has been shown to inhibit LPS-induced NF-κB DNA binding activity and inhibits COX-2 catalytic activity.

Reference

1.Haseloff, R.F.,Mertsch, K.,Rohde, E., et al. Cytotoxicity of spin trapping compounds. FEBS Letters 418, 73-75 (1997).