N-trifluoroacetyl Varenicline

• CAT Number: C000751
• CAS Number: 230615-70-0
• Molecular Formula: C₁₅H₁₂F₃N₃O
• Molecular Weight: 307.27
• Purity: ≥95%
• Synonyms: 2,2,2-Trifluoro-1-(6,7,9,10-tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-yl)ethanone, 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: 2-8°C
• IUPAC Name: 2,2,2-trifluoro-1-(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaen-14-yl)ethanone
• InChI: InChI=1S/C15H12F3N3O/c16-15(17,18)14(22)21-6-8-3-9(7-21)11-5-13-12(4-10(8)11)19-1-2-20-13/h1-2,4-5,8-9H,3,6-7H2
• InChIKey: XDLHBWIAJAKYKF-UHFFFAOYSA-N
• SMILES: C1C2CN(CC1C3=CC4=NC=CN=C4C=C23)C(=O)C(F)(F)F

N-trifluoroacetyl Varenicline (Cat No.:C000751) is a modified derivative of Varenicline, a medication primarily used to aid smoking cessation. This compound contains a trifluoroacetyl group, enhancing its pharmacological properties. Varenicline functions as a partial agonist at nicotinic acetylcholine receptors, both stimulating and blocking their activation to reduce nicotine cravings and withdrawal symptoms. The trifluoroacetyl modification may potentially influence the compound’s receptor binding and metabolic profile. Research into N-trifluoroacetyl Varenicline aims to optimize its effectiveness in smoking cessation therapy, contributing to the development of innovative approaches to combat nicotine addiction.

Reference

Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;