N2’-Deacetyl-N2’-(4-mercapto-4-methyl-1-oxopentyl)-maytansine

• CAT Number: R031089
• CAS Number: 796073-69-3
• Molecular Formula: C₃₈H₅₄ClN₃O₁₀S
• Molecular Weight: 780.37
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-(4-methyl-4-sulfanylpentanoyl)amino]propanoate
• InChI: InChI=1S/C38H54ClN3O10S/c1-21-12-11-13-28(49-10)38(47)20-27(50-35(46)40-38)22(2)33-37(6,52-33)29(51-34(45)23(3)41(7)30(43)14-15-36(4,5)53)19-31(44)42(8)25-17-24(16-21)18-26(48-9)32(25)39/h11-13,17-18,22-23,27-29,33,47,53H,14-16,19-20H2,1-10H3,(H,40,46)/b13-11+,21-12+/t22-,23+,27+,28-,29+,33+,37+,38+/m1/s1
• InChIKey: JFCFGYGEYRIEBE-YVLHJLIDSA-N
• SMILES: C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)S)C)\C)OC)(NC(=O)O2)O

N2’-Deacetyl-N2’-(4-mercapto-4-methyl-1-oxopentyl)-maytansine（Cat No.:R031089）is a derivative of maytansine, a potent cytotoxic agent known for its ability to inhibit microtubule polymerization, leading to cell cycle arrest and apoptosis in cancer cells. This compound features a unique mercapto group, enhancing its reactivity and potential for conjugation to targeted delivery systems, such as antibody-drug conjugates. Its design aims to improve therapeutic efficacy while reducing systemic toxicity. As a promising candidate in anticancer drug development, it offers innovative strategies for targeted cancer therapy and precision medicine.