N2-Methylguanosine

• CAT Number: I019487
• CAS Number: 2140-77-4
• Molecular Formula: C₁₁H₁₅N₅O₅
• Molecular Weight: 297.27
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• IUPAC Name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(methylamino)-1H-purin-6-one
• InChI: InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10-/m1/s1
• InChIKey: SLEHROROQDYRAW-KQYNXXCUSA-N
• SMILES: CNC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

N2-Methylguanosine（Cat No.:I019487）is a modified nucleoside, derived from the methylation of guanosine at the nitrogen position 2 of the purine ring. This modification is commonly found in RNA, where it plays a crucial role in RNA stability, translation, and splicing. N2-Methylguanosine can influence the formation of the RNA cap structure, which is vital for mRNA stability and efficient translation in eukaryotic cells. Additionally, it has been studied for its involvement in cellular processes, such as gene expression regulation and stress response. Its potential therapeutic applications are still under investigation, particularly in cancer and neurodegenerative diseases.

Reference

[1]. Ginell SL, et al. Conformation of N2-methylguanosine, a modified nucleoside of tRNA. Biochem Biophys Res Commun. 1978 Oct 30;84(4):886-94.