N3PT

• CAT Number: I001488
• CAS Number: 13860-66-7
• Molecular Formula: C13H19Cl2N3OS
• Molecular Weight: 336.28
• Purity: ≥95%
• Synonyms: 2-[3-[(2-amino-6-methylpyridin-3-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride
• Target: Transketolase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 22 nM( Apo-TK) ; 26 nM (EC50, Cellular TK) [1]
• InChI: InChI=1S/C13H18N3OS.2ClH/c1-9-3-4-11(13(14)15-9)7-16-8-18-12(5-6-17)10(16)2;;/h3-4,8,17H,5-7H2,1-2H3,(H2,14,15);2*1H/q+1;;/p-1
• InChIKey: ZLGKCAQWOASSTP-UHFFFAOYSA-M
• SMILES: CC1=NC(=C(C=C1)C[N+]2=CSC(=C2C)CCO)N.Cl.[Cl-]

N3PT (N3-[Propenyl-Tetrahydroisoquinoline])(CAT: I001488) is a potent and selective inhibitor of histone demethylase enzymes, extensively used in epigenetics research. It specifically targets lysine demethylases (KDMs), such as KDM2 and KDM4, thereby regulating gene expression and chromatin remodeling. By modulating histone methylation levels, N3PT aids in studying epigenetic mechanisms underlying cancer, neurodegenerative diseases, and developmental disorders. Its high purity and biochemical stability make it suitable for both in vitro assays and cellular studies. As a critical tool in epigenetics, N3PT facilitates the discovery of novel therapeutic interventions and the understanding of transcriptional regulation.