N4-Acetyl-2/'-O-Methyl-cytidine

• CAT Number: M136978
• CAS Number: 113886-71-8
• Molecular Formula: C12H17N3O6
• Molecular Weight: 299.28
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
• InChI: InChI=1S/C12H17N3O6/c1-6(17)13-8-3-4-15(12(19)14-8)11-10(20-2)9(18)7(5-16)21-11/h3-4,7,9-11,16,18H,5H2,1-2H3,(H,13,14,17,19)/t7-,9-,10-,11-/m1/s1
• InChIKey: CYDFBLGNJUNSCC-QCNRFFRDSA-N
• SMILES: CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC

N4-Acetyl-2′-O-Methyl-cytidine（Cat No.:M136978）is a modified nucleoside used in oligonucleotide synthesis and RNA research. The N4-acetyl modification at the cytidine base provides increased stability and reduces susceptibility to enzymatic degradation, while the 2′-O-methyl group enhances RNA stability and resistance to exonucleases. These modifications are valuable for developing RNA-based therapeutics and in studies involving RNA interference (RNAi) and gene regulation. N4-Acetyl-2′-O-Methyl-cytidine is commonly used in the synthesis of chemically modified RNA oligonucleotides to improve their therapeutic potential by enhancing stability and reducing immune activation.