N4-Acetylcytidine triphosphate sodium

• CAT Number: I046168
• CAS Number: 2803886-33-9
• Molecular Formula: C11H14N3Na4O15P3
• Molecular Weight: 613.12
• Purity: ≥95%
• Synonyms: tetrasodium;[[[(2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
• InChI: InChI=1S/C11H18N3O15P3.4Na/c1-5(15)12-7-2-3-14(11(18)13-7)10-9(17)8(16)6(27-10)4-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,6,8-10,16-17H,4H2,1H3,(H,22,23)(H,24,25)(H2,19,20,21)(H,12,13,15,18);;;;/q;4*+1/p-4/t6-,8-,9-,10-;;;;/m1..../s1
• InChIKey: VSBLTNBKSQTQJC-XGZYCNACSA-J
• SMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O.[Na+].[Na+].[Na+].[Na+]

N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro
transcription and it can be incorporated into multiple templates[1].
N4-Acetylcytidine triphosphate sodium (0.1-2 mM; 24-48 h) inhibits BV2 microglia cell grwoth[1].?
N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3-6 h) activates NFκB signaling and upregulates NLRP3 expression[1].?
N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3 h) increases the expression level of HMGB1[1].

Reference

[1]. Sinclair WR, et al. Profiling Cytidine Acetylation with Specific Affinity and Reactivity. ACS Chem Biol. 2017 Dec 15;12(12):2922-2926.
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