N6-(2-Phenylethyl)adenosine

• CAT Number: I020655
• CAS Number: 20125-39-7
• Molecular Formula: C18H21N5O4
• Molecular Weight: 371.39
• Purity: ≥95%
• Synonyms: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(2-phenylethylamino)purin-9-yl]oxolane-3,4-diol
• InChI: InChI=1S/C18H21N5O4/c24-8-12-14(25)15(26)18(27-12)23-10-22-13-16(20-9-21-17(13)23)19-7-6-11-4-2-1-3-5-11/h1-5,9-10,12,14-15,18,24-26H,6-8H2,(H,19,20,21)/t12-,14-,15-,18-/m1/s1
• InChIKey: LGZYEDZSPHLISU-SCFUHWHPSA-N
• SMILES: C1=CC=C(C=C1)CCNC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O

N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively[1].
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) inhibits rA2AR (IC50=560 nM), hA2AR (IC50=2250 nM) in CHO cells[1].

Reference

[1]. Tchilibon S, et al. Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands. Bioorg Med Chem. 2004 May 1;12(9):2021-34.
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