N6-Methyladenosine-d3

• CAT Number: R032144
• CAS Number: 139896-43-8
• Molecular Formula: C11H12D3N5O4
• Molecular Weight: 284.29
• Purity: ≥95%
• Synonyms: (2R,4S,5R)-2-(hydroxymethyl)-5-[6-(trideuteriomethylamino)purin-9-yl]oxolane-3,4-diol
• InChI: InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7?,8+,11-/m1/s1/i1D3
• InChIKey: VQAYFKKCNSOZKM-QCYBPOKRSA-N
• SMILES: [2H]C([2H])([2H])NC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@H](C([C@H](O3)CO)O)O

N6-Methyladenosine-d3(CAT: R032144) is the deuterated form of N6-methyladenosine (m6A), a prominent RNA modification involved in the regulation of mRNA stability, splicing, translation, and degradation. The deuterated version, where three hydrogen atoms are replaced with deuterium, is primarily used in pharmacokinetic studies and molecular biology research. It allows for more precise tracking of m6A-modified RNA in vivo, providing insights into the dynamics of RNA methylation and its role in gene expression regulation. N6-Methyladenosine-d3 is especially valuable in studying the function of RNA modifications in processes like cell differentiation, development, and in the context of neurological disease research, where m6A modifications are implicated in synaptic plasticity and neurodegenerative diseases.