N6-Methyladenosine

• CAT Number: I002413
• CAS Number: 1867-73-8
• Molecular Formula: C11H15N5O4
• Molecular Weight: 281.27
• Purity: ≥95%
• Synonyms: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• Target: Metabolic Enzyme/Protease
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol
• InChI: InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1
• InChIKey: VQAYFKKCNSOZKM-IOSLPCCCSA-N
• SMILES: CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

N6-Methyladenosine (m6A)（Cat No.:I002413）is a modified nucleotide and the most prevalent internal RNA modification in eukaryotic mRNA, influencing various biological processes. It plays a crucial role in RNA stability, splicing, translation, and decay, thereby affecting gene expression regulation. m6A is installed by a methyltransferase complex, removed by demethylases, and recognized by specific “reader” proteins, making it a dynamic and reversible modification. Its regulatory roles are linked to cellular differentiation, stress responses, and diseases like cancer. As a key epitranscriptomic marker, m6A is extensively studied in RNA biology and therapeutic development.

Reference

[1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.
[2]. Jia G, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011 Oct 16;7(12):885-7.