For research use only. Not for therapeutic Use.
N6022（Cat No.:I000781）is a selective, reversible inhibitor of S-nitrosoglutathione reductase (GSNOR), an enzyme that regulates nitric oxide (NO) signaling by metabolizing S-nitrosoglutathione (GSNO). By inhibiting GSNOR, N6022 enhances endogenous NO bioavailability, which can support vascular function, reduce inflammation, and modulate immune responses. N6022 has been studied for therapeutic potential in conditions like asthma, chronic obstructive pulmonary disease (COPD), and cardiovascular disorders, where NO plays a protective role. Its mechanism allows researchers to explore NO-related pathways, making it a valuable tool for studying oxidative stress and inflammation in disease contexts.
| Catalog Number | I000781 |
| CAS Number | 1208315-24-5 |
| Synonyms | 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid |
| Molecular Formula | C24H22N4O3 |
| Purity | ≥95% |
| Target | GSNOR |
| Solubility | DMSO: ≥ 46 mg/mL |
| Storage | Store at -20C |
| IC50 | 10 nM |
| IUPAC Name | 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid |
| InChI | InChI=1S/C24H22N4O3/c1-16-14-18(24(25)31)4-9-21(16)28-20(8-11-23(29)30)7-10-22(28)17-2-5-19(6-3-17)27-13-12-26-15-27/h2-7,9-10,12-15H,8,11H2,1H3,(H2,25,31)(H,29,30) |
| InChIKey | YVPGZQLRPAGKLA-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)C(=O)N)N2C(=CC=C2C3=CC=C(C=C3)N4C=CN=C4)CCC(=O)O |
| Reference | </br>1:Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Green LS, Chun LE, Patton AK, Sun X, Rosenthal GJ, Richards JP.Biochemistry. 2012 Mar 13;51(10):2157-68. doi: 10.1021/bi201785u. Epub 2012 Feb 28. PMID: 22335564 </br>2:A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Colagiovanni DB, Drolet DW, Langlois-Forget E, Piché MP, Looker D, Rosenthal GJ.Regul Toxicol Pharmacol. 2012 Feb;62(1):115-24. doi: 10.1016/j.yrtph.2011.12.012. Epub 2011 Dec 24. PMID: 22210450 |
