nAChR-IN-1

• CAT Number: I042866
• CAS Number: 849461-90-1
• Molecular Formula: C16H31NO2
• Molecular Weight: 269.42
• Purity: ≥95%
• Synonyms: (2,2,6,6-tetramethylpiperidin-4-yl) heptanoate
• InChI: InChI=1S/C16H31NO2/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13/h13,17H,6-12H2,1-5H3
• InChIKey: PWWKJRFUJIFGGD-UHFFFAOYSA-N
• SMILES: CCCCCCC(=O)OC1CC(NC(C1)(C)C)(C)C

nAChR-IN-1 (Cat No.:I042866) is a selective inhibitor of nicotinic acetylcholine receptors (nAChRs), particularly targeting receptors lacking α5, α6, or β3 subunits. In vitro studies demonstrate that at a concentration of 100 nM, nAChR-IN-1 inhibits nAChRs with a 90% inhibition rate in Xenopus oocytes. It also suppresses various acetylcholine receptor subtypes, including mouse muscle-type (α1β1εδ) nAChR and different combinations of rat neuronal alpha and beta subunits (α3β4, α4β2, and α3β2), with IC₅₀ values ranging from 1.0 to 460 nM. In vivo, a single subcutaneous dose of 20 mg/kg in mice improved nicotine-induced hypomotility and hypothermia. This compound is valuable for researching nAChR dysfunctions and neurological disorders.​