For research use only. Not for therapeutic Use.
Several different arachidonoyl amino acids, including N-<wbr></wbr>arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB<sub>1</sub>-<wbr></wbr>selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D<sub>1</sub> and D<sub>2</sub> receptors. NADA is also a potent inhibitor (IC<sub>50</sub> = 0.25 µM) of the proliferation of MCF-<wbr></wbr>7 breast carcinoma cells. Recent reports of NADA’s endothelium-<wbr></wbr>dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-<wbr></wbr>CB<sub>1</sub>/CB<sub>2</sub> dependent.
| Catalog Number | M127085 |
| CAS Number | 199875-69-9 |
| Synonyms | NADA |
| Molecular Formula | C28H41NO3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide |
| InChI | InChI=1S/C28H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-28(32)29-23-22-25-20-21-26(30)27(31)24-25/h6-7,9-10,12-13,15-16,20-21,24,30-31H,2-5,8,11,14,17-19,22-23H2,1H3,(H,29,32)/b7-6-,10-9-,13-12-,16-15- |
| InChIKey | MVVPIAAVGAWJNQ-DOFZRALJSA-N |
| SMILES | CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCC1=CC(=C(C=C1)O)O |
