Nadifloxacin

• CAT Number: I000993
• CAS Number: 124858-35-1
• Molecular Formula: C19H21FN2O4
• Molecular Weight: 360.40
• Purity: ≥95%
• Synonyms: OPC 7251
• Target: Antibacterial
• Solubility: DMSO 20 mg/mL; Water <1 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
• InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
• InChIKey: JYJTVFIEFKZWCJ-UHFFFAOYSA-N
• SMILES: CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O

Nadifloxacin（Cat No.:I000993）is a topical fluoroquinolone antibiotic used primarily to treat skin infections, including acne and bacterial dermatitis. It inhibits bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and repair, effectively stopping bacterial growth. Known for its broad-spectrum action, nadifloxacin is effective against both gram-positive and gram-negative bacteria, including resistant strains like MRSA (methicillin-resistant Staphylococcus aureus). Its strong antibacterial properties and low systemic absorption make it ideal for dermatological applications, offering targeted treatment with minimal side effects. Nadifloxacin is commonly prescribed in topical formulations for its efficacy and safety.

Reference

[1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66.

[2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31.