Nafcillin Sodium

• CAT Number: A000557
• CAS Number: 7177-50-6
• Molecular Formula: C21H21N2O5S • Na [H2O]
• Molecular Weight: 454.50
• Purity: ≥95%
• Synonyms: CL 8491
• Target: Beta-lactamase
• Storage: 3 years -20C powder
• IUPAC Name: sodium;(2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
• InChI: InChI=1S/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1
• InChIKey: OCXSDHJRMYFTMA-KMFBOIRUSA-M
• SMILES: CCOC1=C(C2=CC=CC=C2C=C1)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].O.[Na+]

Nafcillin Sodium（Cat No.:A000557）is a beta-lactamase-resistant penicillin antibiotic specifically designed to treat infections caused by penicillinase-producing Staphylococcus aureus and other Gram-positive bacteria. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. Nafcillin is commonly used to treat conditions like skin and soft tissue infections, bone infections, endocarditis, and respiratory infections. Administered intravenously, it achieves high serum concentrations, making it effective for serious systemic infections. Its stability against beta-lactamase enzymes makes it a reliable choice for staphylococcal infections in hospital settings.

Reference

Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.