For research use only. Not for therapeutic Use.
Naftifine Hydrochloride（Cat No.:A001121）is an antifungal agent used primarily for the treatment of dermatophyte infections, including athlete’s foot, ringworm, and jock itch. As a synthetic allylamine, it works by inhibiting squalene epoxidase, an enzyme involved in the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol production, Naftifine Hydrochloride causes fungal cell membrane destabilization and eventual cell death. This compound is typically administered topically, providing effective, localized treatment with minimal systemic absorption. It offers an efficient solution for managing superficial fungal infections.
| Catalog Number | A001121 |
| CAS Number | 65473-14-5 |
| Synonyms | AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin;(E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride |
| Molecular Formula | C21H21N • HCl |
| Purity | ≥95% |
| Storage | 3 years -20C powder |
| Related CAS | 65472-88-0 (free base) |
| IUPAC Name | (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine;hydrochloride |
| InChI | InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+; |
| InChIKey | OLUNPKFOFGZHRT-YGCVIUNWSA-N |
| SMILES | CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl |
| Reference | 1:Efficacy and Safety of Naftifine HCl Cream 2% in the Treatment of Pediatric Subjects With Tinea Corporis. Gold M, Dhawan S, Verma A, Kuligowski M, Dobrowski D.J Drugs Dermatol. 2016 Jun 1;15(6):743-8. PMID: 27272083 |
