For research use only. Not for therapeutic Use.
NAG-thiazoline is a O-GlcNAcase inhibitor with a Ki of 180 nM. NAG-thiazoline is a potent GH20 GlcNAcase (VhGlcNAcase) inhibitor with an IC50 of 11.9 μM and a Ki of 62 µM[1].
NAG-thiazoline completely inhibits the growth of V. campbellii strain 650 with a MIC value of 0.5 µM[1].
| Catalog Number | R018410 |
| CAS Number | 179030-22-9 |
| Synonyms | (3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol |
| Molecular Formula | C8H13NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C8H13NO4S/c1-3-9-5-7(12)6(11)4(2-10)13-8(5)14-3/h4-8,10-12H,2H2,1H3/t4-,5-,6-,7-,8-/m1/s1 |
| InChIKey | DRHXTSWSUAJOJZ-FMDGEEDCSA-N |
| SMILES | CC1=NC2C(C(C(OC2S1)CO)O)O |
| Reference | [1]. Macauley MS, et al. Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochim Biophys Acta. 2010 Feb;1800(2):107-21. [2]. Piyanat Meekrathok, et al. NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase. FEBS J. 2020 Nov;287(22):4982-4995. |
