For research use only. Not for therapeutic Use.
A narcotic used as a pain medication. Nalbuphine appears to be an agonist at κ-opioid receptors and an antagonist or partial agonist at μ-opioid receptors (IC50 of 36 nM and 11 nM resp).
| Catalog Number | I033023 |
| CAS Number | 23277-43-2 |
| Molecular Formula | C21H27NO4.HCl |
| Purity | ≥95% |
| IUPAC Name | (4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol;hydrochloride |
| InChI | InChI=1S/C21H27NO4.ClH/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H/t15-,16+,19-,20-,21+;/m0./s1 |
| SMILES | C1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O.Cl |
| Reference | P Gharagozlou et al. Activity of opioid ligands in cells expressing cloned µ opioid receptors. B.M.C. Pharmacol. 2003, 3, 1-8.
K Yasuda et al. Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA. 1993, 90, 6736-6740. |
