Nalidixic acid sodium salt

• CAT Number: R004476
• CAS Number: 3374-05-8
• Molecular Formula: C12H11N2NaO3
• Molecular Weight: 254.22
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• Storage: 2-8°C
• IUPAC Name: sodium;1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
• InChI: InChI=1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
• InChIKey: ROKRAUFZFDQWLE-UHFFFAOYSA-M
• SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)[O-].[Na+]

Nalidixic Acid Sodium Salt（Cat No.:R004476）is a synthetic antibacterial agent belonging to the quinolone class, primarily effective against Gram-negative bacteria. It functions by inhibiting bacterial DNA gyrase, thereby impeding DNA replication and transcription. This sodium salt form enhances solubility, facilitating use in aqueous formulations. Nalidixic Acid is widely used in urinary tract infections and is valuable in treating infections caused by pathogens like Escherichia coli and Klebsiella. Its role in early antibiotic therapies paved the way for the development of newer quinolones with broader antibacterial spectra and clinical applications.

Reference

Levitt, Martin, and et al. /Studies on the Mechanism of Action of Nalidixic Acid./ Studies on the Mechanism of Action of Nalidixic Acid 4.4 (1973): 479-86. www.ncbi.gov. Web. 10 Sept. 2012.