For research use only. Not for therapeutic Use.
Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.<br>Naloxone significantly reduces the LPS-induced degeneration of the midbrain neurons. Naloxone inactives stereoisomer (+)-naloxone protected the dopaminergic neurons with equal potency. Naloxone inhibits LPS-induced activation of microglia and release of proinflammatory factors, and inhibition of microglia generation of superoxide free radical best correlated with the neuroprotective effect of naloxone isomers. Naloxone is found to partially inhibit the binding of [(3)H]LPS to cell membranes, whereas it failes to prevent damage to dopaminergic neurons by peroxynitrite, a product of nitric oxide and superoxide.<br>Naloxone (10 mg/kg) causes a dose-dependent reduction of break-points and locomotor activity in both the beer and near-beer rats.
| Catalog Number | A000537 |
| CAS Number | 357-08-4 |
| Synonyms | NA |
| Molecular Formula | C19H21NO4 • HCl |
| Purity | ≥95% |
| Target | Opioid receptor |
| Storage | 3 years -20C powder |
| InChIKey | RGPDIGOSVORSAK-STHHAXOLSA-N |
