For research use only. Not for therapeutic Use.
Nampt activator-1 (compound 1) is a potent Nicotinamide phosphoribosyltransferase (NAMPT) activator, with EC50 of 3.3-3.7 μM[1].
| Catalog Number | I041766 |
| CAS Number | 701929-65-9 |
| Synonyms | ethyl 4-(pyridin-4-ylmethylcarbamoylamino)benzoate |
| Molecular Formula | C16H17N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H17N3O3/c1-2-22-15(20)13-3-5-14(6-4-13)19-16(21)18-11-12-7-9-17-10-8-12/h3-10H,2,11H2,1H3,(H2,18,19,21) |
| InChIKey | LNIPYBUMGBKFKQ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC=C(C=C1)NC(=O)NCC2=CC=NC=C2 |
| Reference | [1]. Akiu M, et al. Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.[J]. Bioorganic & medicinal chemistry letters, 2021, 43:128048. |
