Nampt-IN-10 TFA

• CAT Number: I042919
• CAS Number: 2567724-20-1
• Molecular Formula: C27H28FN5O2..xC2HF3O2
• Purity: ≥95%

​Nampt-IN-10 TFA（Cat No.:I042919）is a potent inhibitor of Nicotinamide Phosphoribosyltransferase (NAMPT), an enzyme crucial for NAD⁺ biosynthesis. It exhibits significant cytotoxicity against cancer cell lines, including A2780 (IC₅₀ = 5 nM) and CORL23 (IC₅₀ = 19 nM). Notably, Nampt-IN-10 TFA serves as a novel non-antimitotic payload for antibody-drug conjugates (ADCs), offering an alternative to traditional antimitotic agents. This compound’s efficacy highlights its potential in targeted cancer therapies, particularly in the development of ADCs designed to deliver cytotoxic agents directly to tumor cells.