Nampt-IN-3

• CAT Number: I019119
• CAS Number: 2121591-52-2
• Molecular Formula: C₂₉H₂₅N₇O₂
• Molecular Weight: 503.55
• Purity: ≥95%
• Target: Epigenetics
• Storage: Store at -20°C
• IUPAC Name: N-(2-aminophenyl)-4-[[4-[4-(pyridin-3-ylmethylcarbamoyl)phenyl]triazol-1-yl]methyl]benzamide
• InChI: InChI=1S/C29H25N7O2/c30-25-5-1-2-6-26(25)33-29(38)24-9-7-20(8-10-24)18-36-19-27(34-35-36)22-11-13-23(14-12-22)28(37)32-17-21-4-3-15-31-16-21/h1-16,19H,17-18,30H2,(H,32,37)(H,33,38)
• InChIKey: LSGNVZAEAAZOEH-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CN3C=C(N=N3)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5

Nampt-IN-3（Cat No.:I019119）is a selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential in NAD+ biosynthesis and cellular energy metabolism. By inhibiting NAMPT, Nampt-IN-3 disrupts NAD+ production, particularly affecting highly metabolic cells, like cancer cells, which rely on NAMPT for survival under stress conditions. This compound shows promise in cancer research, as NAMPT inhibition can lead to apoptosis in certain tumor types. Nampt-IN-3 serves as a valuable tool for studying NAD+-dependent processes, metabolic pathways, and potential therapeutic strategies targeting energy metabolism in oncology.

Reference

[1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.