Nanchangmycin

For research use only. Not for therapeutic Use.

  • CAT Number: I004455
  • CAS Number: 65101-87-3
  • Molecular Formula: C47H77O14 • Na
  • Molecular Weight: 889.10
  • Purity: ≥95%
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Nanchangmycin(Cat No.:I004455)is a potent polyether antibiotic used primarily in agricultural and pharmaceutical applications. It exhibits strong antimicrobial activity, particularly against Gram-positive bacteria and some fungi. Nanchangmycin works by disrupting cellular membrane potential, inhibiting the growth and replication of target microorganisms. This compound has shown potential as an agent in the treatment of various infections, especially those caused by resistant strains. Its unique mechanism of action and broad-spectrum efficacy make it a valuable candidate for further research in the development of novel antimicrobial therapies.


Catalog Number I004455
CAS Number 65101-87-3
Synonyms

(2S,4R,6E,8S)-8-[(2S,2/’R,4/’S,5R,5/’S,7R,7/’R,8R,9S,9/’S,10/’R)-9-hydroxy-2,4/’,8,10/’-tetramethyl-2/’-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9/’-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy

Molecular Formula C47H77O14 • Na
Purity ≥95%
Solubility DMSO ≥ 30 mg/mL
Storage 3 years -20C powder
IUPAC Name sodium;(E,2S,4R,8S)-8-[(2S,5R,7S,8R,9R)-7-hydroxy-2-[(2R,4S,5S,7R,9S,10R)-2-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-9-[(2S,5S,6R)-5-methoxy-6-methyloxan-2-yl]oxy-4,10-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl]-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-2,4,6-trimethyl-5-oxonon-6-enoate
InChI InChI=1S/C47H78O14.Na/c1-24(40(50)25(2)18-28(5)43(51)52)17-26(3)41-31(8)34(49)22-45(59-41)16-15-44(11,61-45)38-21-36(56-39-14-13-35(54-12)33(10)55-39)32(9)47(58-38)30(7)20-37(57-47)42-27(4)19-29(6)46(53,23-48)60-42;/h17,25-39,41-42,48-49,53H,13-16,18-23H2,1-12H3,(H,51,52);/q;+1/p-1/b24-17+;/t25-,26+,27+,28+,29-,30+,31-,32-,33-,34+,35+,36+,37-,38-,39-,41-,42+,44+,45-,46+,47+;/m1./s1
InChIKey XMAIRYYXDCNFKP-SEDNIUBGSA-M
SMILES C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@]3(O2)[C@@H]([C@H](C[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)/C=C(\C)/C(=O)[C@H](C)C[C@H](C)C(=O)[O-])C)O)C)O[C@@H]6CC[C@@H]([C@H](O6)C)OC)C)C)(CO)O)C.[Na+]
Reference

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<br>[1]. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58.

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