Nanvuranlat (JPH203)

• CAT Number: I007458
• CAS Number: 1037592-40-7
• Molecular Formula: C23H19Cl2N3O4
• Molecular Weight: 472.32
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N

Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.

Reference

[1] Yun DW, et al. J Pharmacol Sci. 2014, 124(2):208-17.
[2] Choi DW, et al. Korean J Physiol Pharmacol. 2017, 21(6):599-607.
[3] Wempe MF, et al. Drug Metab Pharmacokinet. 2012, 27(1):155-61.
[4] Yothaisong S, et al. Tumour Biol. 2017, 39(3):1010428317694545.