Naphthol AS-TR phosphate disodium

• CAT Number: I040187
• CAS Number: 4264-93-1
• Molecular Formula: C18H13ClNNa2O5P
• Molecular Weight: 435.71
• Purity: ≥95%
• Synonyms: disodium;[3-[(4-chloro-2-methylphenyl)carbamoyl]naphthalen-2-yl] phosphate
• InChI: InChI=1S/C18H15ClNO5P.2Na/c1-11-8-14(19)6-7-16(11)20-18(21)15-9-12-4-2-3-5-13(12)10-17(15)25-26(22,23)24;;/h2-10H,1H3,(H,20,21)(H2,22,23,24);;/q;2*+1/p-2
• InChIKey: TYCHZTPSWMGRRI-UHFFFAOYSA-L
• SMILES: CC1=C(C=CC(=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2OP(=O)([O-])[O-].[Na+].[Na+]

Naphthol AS-TR phosphate disodium (Cat No.: I040187) is a water-soluble substrate commonly used in enzyme histochemistry and cytochemistry. It acts as a substrate for alkaline phosphatase and is used in various diagnostic and research applications to visualize enzyme activity. Upon enzymatic hydrolysis, it forms a colored product that can be observed under a microscope, allowing researchers to study the distribution and activity of alkaline phosphatase in tissues. This compound is often employed in immunohistochemistry and biochemical assays to enhance detection sensitivity.

Reference

[1]. V Souvannavong, et al. Expression of alkaline phosphatase by a B-cell hybridoma and its modulation during cell growth and apoptosis, Immunol Lett. 1995 Sep;47(3):163-70.
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