Narasin

• CAT Number: A000024
• CAS Number: 55134-13-9
• Molecular Formula: C43H72O11
• Molecular Weight: 765.00
• Purity: ≥95%
• Synonyms: (4S)-4-Methylsalinomycin; A 28086A; Antibiotic A 28086A; Antibiotic C 7819B; C 7819B; Monteban; Narasin A; Narasul
• Target: Apoptosis
• Storage: Desiccate at -20C
• IUPAC Name: (2R)-2-[(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyloxan-2-yl]butanoic acid
• InChI: InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
• InChIKey: VHKXXVVRRDYCIK-CWCPJSEDSA-N
• SMILES: CC[C@H]([C@H]1[C@H](C[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C)C(=O)O

Narasin（Cat No.:A000024）is a polyether ionophore antibiotic primarily used as a growth promoter and coccidiostat in poultry and livestock. It functions by binding to metal ions such as potassium, sodium, and calcium, disrupting the ionic balance across cell membranes and inhibiting pathogen growth. Narasin is particularly effective against Eimeria species, responsible for coccidiosis in animals. Additionally, it has been studied for its antimicrobial properties and potential use in controlling bacterial infections. Due to its action on ion channels, Narasin is of interest for its potential applications in pharmacology and animal health.

Reference

The isolation and characterization of narasin, a new polyether antibiotic. Berg D.H. & Hamill R.L. J. Antibiot. 1978, 31, 1.