For research use only. Not for therapeutic Use.
Naratriptan (Cat.No:I000820) is a medication used for the treatment of acute migraine attacks. It belongs to a class of drugs known as triptans, which work by narrowing blood vessels in the brain and reducing inflammation. Naratriptan is effective in relieving migraine symptoms such as headache, nausea, and sensitivity to light and sound. It is available in oral tablets and should be taken as soon as the migraine symptoms begin for optimal efficacy.
| Catalog Number | I000820 |
| CAS Number | 121679-13-8 |
| Molecular Formula | C17H25N3O2S |
| Purity | ≥95% |
| Target | 5-HT1 Receptor |
| Solubility | DMSO 74 mg/mL (198 mM); Water 22 mg/mL (59 mM) |
| Storage | Store at +4C |
| Reference | </br>1:Preparation and Optimization of Fast Dissolving Film of Naratriptan Hydrochloride. Koradia KD, Sidhdhapara PT, Sheth NR.Recent Pat Drug Deliv Formul. 2017 Feb 12. doi: 10.2174/1872211311666170213105001. [Epub ahead of print] PMID: 28201962 </br>2:Quantitative structure-retention relationship model for the determination of naratriptan hydrochloride and its impurities based on artificial neural networks coupled with genetic algorithm. Mizera M, Krause A, Zalewski P, Skibiński R, Cielecka-Piontek J.Talanta. 2017 Mar 1;164:164-174. doi: 10.1016/j.talanta.2016.11.041. Epub 2016 Nov 20. PMID: 28107913 </br>3:Oral transmucosal delivery of naratriptan. Sattar M, Lane ME.Int J Pharm. 2016 Nov 30;514(1):263-269. doi: 10.1016/j.ijpharm.2016.06.039. PMID: 27863671 </br>4:Isolated naratriptan-associated ischemic colitis. Akbar A, Nissan G, Chaudhry P, Rangasamy P, Mudrovich S.Proc (Bayl Univ Med Cent). 2016 Oct;29(4):410-411. PMID: 27695179 Free PMC Article</br>5:Naratriptan aggregation in lipid bilayers: perspectives from molecular dynamics simulations. Wood I, Pickholz M.J Mol Model. 2016 Sep;22(9):221. doi: 10.1007/s00894-016-3096-8. Epub 2016 Aug 24. PMID: 27558798 </br>6:Development and Validation of Stability-Indicating HPTLC Method for Estimation of Naratriptan Hydrochloride in Its Pharmaceutical Dosage Form and Its Content Uniformity Testing. Prajapati PB, Chotalia J, Bodiwala KB, Marolia BP, Shah SA.J Chromatogr Sci. 2016 Aug;54(7):1129-36. doi: 10.1093/chromsci/bmw080. PMID: 27406125 </br>7:Preparation, characterization and buccal permeation of naratriptan. Sattar M, Hadgraft J, Lane ME.Int J Pharm. 2015 Sep 30;493(1-2):146-51. doi: 10.1016/j.ijpharm.2015.07.035. Epub 2015 Jul 18. PMID: 26196276 </br>8:Final results from the 16-year sumatriptan, naratriptan, and treximet pregnancy registry. Ephross SA, Sinclair SM.Headache. 2014 Jul-Aug;54(7):1158-72. doi: 10.1111/head.12375. Epub 2014 May 7. PMID: 24805878 </br>9:Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride. Stange U, Führling C, Gieseler H.J Pharm Sci. 2014 Apr;103(4):1233-45. doi: 10.1002/jps.23896. Epub 2014 Feb 15. PMID: 24532095 </br>10:Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G.Nat Med. 2012 Oct;18(10):1531-8. doi: 10.1038/nm.2932. Epub 2012 Sep 30. PMID: 23023499 |
