Naspm trihydrochloride

• CAT Number: I000273
• CAS Number: 1049731-36-3
• Molecular Formula: C22H34N4O • 3HCl
• Molecular Weight: 479.31
• Purity: ≥95%
• Synonyms: N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
• Target: Neuronal Signaling
• Solubility: DMSO: ≤ 6.4 mg/mL (Need ultrasonic)
• Storage: Desiccate at +4C
• IUPAC Name: N-[3-[4-(3-aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide;trihydrochloride
• InChI: InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
• InChIKey: JNEOJAUJWOPWJS-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl

NASPM trihydrochloride(CAT: I000273) (Naphthylacetylspermine) is a selective blocker of calcium-permeable AMPA receptors (CP-AMPARs), a subtype of glutamate receptors that play a critical role in synaptic plasticity and excitotoxicity. By specifically inhibiting CP-AMPARs, NASPM reduces calcium influx, making it a valuable tool in neuroscience research for studying synaptic transmission, plasticity, and neurodegenerative processes. Its ability to modulate excitatory neurotransmission provides insights into conditions such as ischemic brain injury, epilepsy, and chronic pain, where CP-AMPARs contribute to pathological signaling. NASPM trihydrochloride is widely used to explore AMPA receptor subunit composition and their roles in physiological and pathological states.