Nateglinide-d5 Ethyl Ester

• CAT Number: R053892
• CAS Number: 1356929-50-4
• Molecular Formula: C21H31NO3
• Molecular Weight: 350.514
• Purity: ≥95%
• Synonyms: N-[[trans-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-(phenyl-d5)alanine Ethyl Ester
• Storage: -20°C
• IUPAC Name: ethyl (2R)-3-(2,3,4,5,6-pentadeuteriophenyl)-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoate
• InChI: InChI=1S/C21H31NO3/c1-4-25-21(24)19(14-16-8-6-5-7-9-16)22-20(23)18-12-10-17(11-13-18)15(2)3/h5-9,15,17-19H,4,10-14H2,1-3H3,(H,22,23)/t17?,18?,19-/m1/s1/i5D,6D,7D,8D,9D
• InChIKey: AVOHCDLQBWDQOF-MRVSTDCPSA-N
• SMILES: CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2CCC(CC2)C(C)C

Nateglinide-d5 Ethyl Ester is a deuterated form of nateglinide, an oral antidiabetic medication used to manage blood glucose levels in type 2 diabetes. In this version, five hydrogen atoms are replaced with deuterium, enhancing its utility in pharmacokinetic and metabolic studies. The ethyl ester modification improves the compound’s solubility and stability. The deuterium labeling allows for precise tracking and analysis using mass spectrometry and NMR spectroscopy, facilitating detailed research into the drug’s absorption, distribution, metabolism, and excretion, while retaining its pharmacological properties.