For research use only. Not for therapeutic Use.
Sodium channel blocker, potent and selective at voltage-gated Nav1.7 (SCN9A); with Nav1.7 pIC50 6.75 and Nav1.5 pIC50 <4.48
Catalog Number | I047565 |
CAS Number | 1315451-25-2 |
Molecular Formula | C20H16Cl2F3N3O3 |
Purity | ≥95% |
IUPAC Name | 2-[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-N-[[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]acetamide |
InChI | InChI=1S/C20H16Cl2F3N3O3/c1-11-13(19(28-31-11)18-14(21)3-2-4-15(18)22)7-16(29)26-8-12-5-6-17(27-9-12)30-10-20(23,24)25/h2-6,9H,7-8,10H2,1H3,(H,26,29) |
SMILES | CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)CC(=O)NCC3=CN=C(C=C3)OCC(F)(F)F |
Reference | I Macsari et al. Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship. Bioorg. Med. Chem. Lett. 2011, 21(13), 3871-3876. |