NB-598 hydrochloride

• CAT Number: I001414
• CAS Number: 136719-25-0
• Molecular Formula: C27H32ClNOS2
• Molecular Weight: 486.13
• Purity: ≥95%
• Synonyms: (E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine;hydrochloride
• Target: Squalene epoxidase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C27H31NOS2.ClH/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23;/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3;1H/b8-6+
• InChIKey: WDXQLZXORYGXJN-WVLIHFOGSA-N
• SMILES: CCN(C/C=C/C#CC(C)(C)C)CC1=CC(=CC=C1)OCC2=CC(=CS2)C3=CSC=C3.Cl

NB-598(CAT: I001414) is a potent and selective competitive inhibitor of squalene epoxidase (SE), a key enzyme in the cholesterol biosynthesis pathway. By inhibiting SE, NB-598 disrupts the conversion of squalene to squalene-2,3-epoxide, effectively reducing cholesterol synthesis. Additionally, NB-598 suppresses triglyceride biosynthesis by modulating the farnesol pathway, which links sterol metabolism to lipid regulation. This compound is a valuable tool in lipid metabolism research, particularly for studying cholesterol homeostasis, triglyceride synthesis, and the development of therapies targeting hyperlipidemia and cardiovascular diseases. Its dual action provides insights into the interplay between cholesterol and triglyceride biosynthetic pathways.