For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway.<br>IC50 value:<br>Target: squalene epoxidase<br>SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibited by NB-598.</p>
| Catalog Number | I001414 |
| CAS Number | 136719-25-0 |
| Synonyms | (E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine;hydrochloride |
| Molecular Formula | C27H32ClNOS2 |
| Purity | ≥95% |
| Target | Squalene epoxidase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| Reference | <p style=/line-height:25px/> <br>[2]. Horie M, Iwasawa Y, Satoh T et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. <br>[3]. Horie M, Hayashi M, Satoh T et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51. <br>[4]. Hidaka Y, Hotta H, Nagata Y, et al. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. J Biol Chem. 1991 Jul 15;266(20):13171-7. <br>[5]. Horie M, Tsuchiya Y, Hayashi M, et al. NB-598: a potent competitive inhibitor of squalene epoxidase. J Biol Chem. 1990 Oct 25;265(30):18075-8. </p> |
