NB-598

• CAT Number: I001189
• CAS Number: 131060-14-5
• Molecular Formula: C27H31NOS2
• Molecular Weight: 449.67
• Purity: ≥95%
• Synonyms: (E)-N-(3-([3,3/’-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine
• Target: Squalene epoxidase
• Solubility: DMSO 14 mg/ml
• Storage: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• IUPAC Name: (E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine
• InChI: InChI=1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+
• InChIKey: KIRGLCXNEVICOG-SOFGYWHQSA-N
• SMILES: CCN(CC=CC#CC(C)(C)C)CC1=CC(=CC=C1)OCC2=CC(=CS2)C3=CSC=C3

NB-598（Cat No.:I001189） is a powerful competitive inhibitor of squalene epoxidase (SE), an enzyme involved in cholesterol biosynthesis. By inhibiting SE, NB-598 effectively suppresses triglyceride biosynthesis via the farnesol pathway. This pathway plays a crucial role in the production of triglycerides, a type of lipid involved in energy storage. By targeting SE, NB-598 disrupts the normal synthesis of triglycerides, providing a potential therapeutic approach for conditions related to abnormal lipid metabolism.

Reference

[1]. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.

[2]. Horie M, Iwasawa Y, Satoh T et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.

[3]. Horie M, Hayashi M, Satoh T et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

[4]. Hidaka Y, Hotta H, Nagata Y, et al. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. J Biol Chem. 1991 Jul 15;266(20):13171-7.

[5]. Horie M, Tsuchiya Y, Hayashi M, et al. NB-598: a potent competitive inhibitor of squalene epoxidase. J Biol Chem. 1990 Oct 25;265(30):18075-8.