NBD-556

• CAT Number: I003205
• CAS Number: 333353-44-9
• Molecular Formula: C17H24ClN3O2
• Molecular Weight: 337.8
• Purity: ≥95%
• Synonyms: N/’-(4-chlorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• Target: gp120/CD4
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: ZKXLQCIOURANAD-UHFFFAOYSA-N

NBD-556 (Cat.No:I003205) is a small molecule compound that acts as a selective inhibitor of the Janus kinase 2 (JAK2) signaling pathway. It has shown promising potential for the treatment of various diseases, including myeloproliferative neoplasms and autoimmune disorders. NBD-556 selectively targets JAK2, a key enzyme involved in regulating immune responses and cell proliferation. Ongoing research aims to further explore its therapeutic applications.

Reference

[1]. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858.

[2]. Sch?n A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB 3rd, Sodroski J, Freire E.
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry. 2006 Sep 12;45(36):10973-80.

[3]. Singh IP, Chauthe SK.
Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010.
Expert Opin Ther Pat. 2011 Mar;21(3):399-416.

[4]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK.
Identification of N-phenyl-N/’-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.
Virology. 2005 Sep 1;339(2):213-25.