NBD-556

• CAT Number: I003205
• CAS Number: 333353-44-9
• Molecular Formula: C17H24ClN3O2
• Molecular Weight: 337.80
• Purity: ≥95%
• Synonyms: N/’-(4-chlorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• Target: HIV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N'-(4-chlorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• InChI: InChI=1S/C17H24ClN3O2/c1-16(2)9-13(10-17(3,4)21-16)20-15(23)14(22)19-12-7-5-11(18)6-8-12/h5-8,13,21H,9-10H2,1-4H3,(H,19,22)(H,20,23)
• InChIKey: ZKXLQCIOURANAD-UHFFFAOYSA-N
• SMILES: CC1(CC(CC(N1)(C)C)NC(=O)C(=O)NC2=CC=C(C=C2)Cl)C

NBD-556（Cat No.:I003205）is a high-purity small-molecule compound used in HIV research. It functions as a CD4 mimetic, binding to the gp120 envelope protein of HIV-1 and facilitating viral entry into host cells. NBD-556 is instrumental in studying the mechanisms of HIV infection and the structural dynamics of the HIV-1 gp120-CD4 interaction. Its unique activity provides insights into viral entry pathways and supports the development of novel therapeutic strategies targeting HIV. High purity ensures its reliability in experimental and preclinical studies, advancing research in virology and drug discovery.

Reference

[1]. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858.

[2]. Sch?n A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB 3rd, Sodroski J, Freire E.
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry. 2006 Sep 12;45(36):10973-80.

[3]. Singh IP, Chauthe SK.
Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010.
Expert Opin Ther Pat. 2011 Mar;21(3):399-416.

[4]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK.
Identification of N-phenyl-N/’-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.
Virology. 2005 Sep 1;339(2):213-25.