NBD-557

• CAT Number: I003204
• CAS Number: 333352-59-3
• Molecular Formula: C17H24BrN3O2
• Molecular Weight: 382.30
• Purity: ≥95%
• Synonyms: N/’-(4-bromophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• Target: HIV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N'-(4-bromophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• InChI: InChI=1S/C17H24BrN3O2/c1-16(2)9-13(10-17(3,4)21-16)20-15(23)14(22)19-12-7-5-11(18)6-8-12/h5-8,13,21H,9-10H2,1-4H3,(H,19,22)(H,20,23)
• InChIKey: QQRFLGRIDNNARB-UHFFFAOYSA-N
• SMILES: CC1(CC(CC(N1)(C)C)NC(=O)C(=O)NC2=CC=C(C=C2)Br)C

NBD-557（Cat No.:I003204）is a high-purity small-molecule compound used in HIV research. As a CD4 mimetic, it binds to the gp120 envelope glycoprotein of HIV-1, facilitating the study of viral entry mechanisms. Unlike NBD-556, NBD-557 is modified to enhance binding affinity and improve biological activity, making it a valuable tool for investigating the interaction between HIV-1 gp120 and host cell receptors. It is instrumental in developing therapeutic strategies targeting viral entry, aiding in the discovery of innovative approaches for HIV treatment.

Reference

[1]. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858.
[2]. Sch?n A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB 3rd, Sodroski J, Freire E. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45(36):10973-80.
[3]. Singh IP, Chauthe SK. Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010. Expert Opin Ther Pat. 2011 Mar;21(3):399-416.
[4]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N/’-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339(2):213-25.