NBI-27914

• CAT Number: M035980
• CAS Number: 184241-44-9
• Molecular Formula: C18H20Cl4N4
• Molecular Weight: 434.19
• Purity: ≥95%
• Synonyms: 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine
• InChI: InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
• InChIKey: KNADXBVKFAUMCR-UHFFFAOYSA-N
• SMILES: CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C

NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily[1].

Reference

[1]. Liaw CW, et al. Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors. Mol Endocrinol. 1997;11(13):2048-2053.
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