For research use only. Not for therapeutic Use.
A high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABAA receptors; NBI 34060 modulates specific GABAA receptor subtypes at the benzodiazepine site; nonbenzodiazepine hypnotic
| Catalog Number | I003152 |
| CAS Number | 325715-02-4 |
| Molecular Formula | C20H17N4O2S |
| Purity | ≥95% |
| IUPAC Name | N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide |
| InChI | InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 |
| SMILES | CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4 |
| Reference | RE Petroski et al. Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors. J. Pharmacol. Exp. Ther. 2006, 317(1), 369-77.
SK Sullivan et al. Characterization of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative/Hypnotic, with the GABAA Receptor. J. Pharmacol. Exp. Ther. 2004, 311(2), 537-546. |
