NBI-42902

• CAT Number: I008252
• CAS Number: 352290-60-9
• Molecular Formula: C27H24F3N3O3
• Molecular Weight: 495.49
• Purity: ≥95%
• Synonyms: 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
• InChI: InChI=1S/C27H24F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h3-13,22H,14-15,31H2,1-2H3/t22-/m0/s1
• InChIKey: CJUWBZDJMYYRDG-QFIPXVFZSA-N
• SMILES: CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)F)CC(C3=CC=CC=C3)N)C4=C(C(=CC=C4)OC)F

NBI-42902 (Cat No.: I008252) is a potent and selective TYK2 (tyrosine kinase 2) inhibitor, designed to modulate the JAK-STAT signaling pathway involved in immune responses and inflammation. By selectively inhibiting TYK2, NBI-42902 suppresses cytokine signaling, including IL-12, IL-23, and type I interferons, without broadly affecting JAK1/2/3. It is a valuable tool in research on autoimmune diseases such as psoriasis, lupus, and inflammatory bowel disease. NBI-42902 enables targeted exploration of TYK2’s role in immune regulation. For research use only in laboratory settings.

Reference

[1]. Struthers RS, et al. Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902. Endocrinology. 2007 Feb;148(2):857-67.
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