NBI-98782

• CAT Number: I005104
• CAS Number: 85081-18-1
• Molecular Formula: C19H29NO3
• Molecular Weight: 319.44
• Purity: ≥95%
• Synonyms: (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
• Target: Monoamine Transporter
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 0.97± 0.48 nM [1]

NBI-98782 (Cat.No:I005104) is a potent and selective antagonist of the histamine H3 receptor, which plays a role in regulating neurotransmitter release and cognitive function. By blocking H3 receptors, NBI-98782 can enhance the release of certain neurotransmitters, such as dopamine and norepinephrine, leading to potential therapeutic effects in cognitive disorders and other neurological conditions. Further research is being conducted to explore its clinical applications.

Reference

[1]. Kilbourn M, et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24;278(3):249-52.