For research use only. Not for therapeutic Use.
NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1].
NCC-149 (5 μM; 3 days) remarkably reduces NeuN expression levels in P19 cells[1].
NCC-149 (0-40 μM; 4 days) reduces embryoid body size in a dose-dependent manner[1].
NCC-149 (5 and 20 μM; 24 h) downregulates P19 cell proliferation[1].
NCC-149 (2.5 and 5 μM; 24 h) leads to cell growth retardation by G2/M phase arrest[1].
| Catalog Number | M014188 |
| CAS Number | 1316652-41-1 |
| Synonyms | N-hydroxy-3-[1-(phenylsulfanylmethyl)triazol-4-yl]benzamide |
| Molecular Formula | C16H14N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14N4O2S/c21-16(18-22)13-6-4-5-12(9-13)15-10-20(19-17-15)11-23-14-7-2-1-3-8-14/h1-10,22H,11H2,(H,18,21) |
| InChIKey | DORPIZJGSLWDIY-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)SCN2C=C(N=N2)C3=CC(=CC=C3)C(=O)NO |
| Reference | [1]. Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. |
