For research use only. Not for therapeutic Use.
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].
NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].
| Catalog Number | I033099 |
| CAS Number | 714240-31-0 |
| Synonyms | 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-1H-quinolin-2-one |
| Molecular Formula | C18H12FN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H12FN3O3/c1-24-13-6-7-15-11(8-13)9-14(17(23)20-15)16-21-18(25-22-16)10-2-4-12(19)5-3-10/h2-9H,1H3,(H,20,23) |
| InChIKey | FJQADEHMIMENRE-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F |
| Reference | [1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525. |
