NCGC00244536

For research use only. Not for therapeutic Use.

  • CAT Number: I012063
  • CAS Number: 2003260-55-5
  • Molecular Formula: C17H16O4
  • Molecular Weight: 284.31
  • Purity: 98%
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NCGC00244536 (Cat No.: I012063), is a potent inhibitor of the enzyme KDM4B, with an impressive IC50 value of 10 nanomolar (nM). KDM4B is involved in epigenetic regulation, particularly in processes related to gene expression. Beyond its action on KDM4B, NCGC00244536 also exhibits noteworthy potency in inhibiting the growth of various cancer cell lines, including breast cancer cell lines like MDA-MB2 and MCF-7, with IC50 values in the micromolar range. This suggests its potential as a valuable compound in cancer research, particularly for investigating epigenetic mechanisms and the development of targeted therapies for cancer treatment.


Catalog Number I012063
CAS Number 2003260-55-5
Synonyms

3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-benzamide;

Molecular Formula C17H16O4
Purity 98%
Target Histone Demethylase
Solubility DMSO
Appearance Crystalline solid
Storage Store at -20°C
Analysis method HPLC
IUPAC Name 3-(8-hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide
InChI InChI=1S/C25H22N2O2/c28-23-17-22(16-20-12-6-13-26-24(20)23)19-10-4-11-21(15-19)25(29)27-14-5-9-18-7-2-1-3-8-18/h1-4,6-8,10-13,15-17,28H,5,9,14H2,(H,27,29)
InChIKey NYKBXXGHEMXSBB-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)CCCNC(=O)C2=CC=CC(=C2)C3=CC(=C4C(=C3)C=CC=N4)O

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